Letters from MGH re Dr. Fasano’s celiac screening today: I don’t have celiac, but I have this! I get so excited by lab results, even if they’re kind of bad. Or neutral. I just like to know. Joe has nothing. He is not a player in this game.
DQ8 is commonly linked to autoimmune disease in the human population. DQ8 is the second most predominant isoform linked to coeliac disease and the DQ most linked to juvenile diabetes. DQ8 increases the risk for rheumatoid arthritis and is linked to the primary risk locus for RA, HLA-DR4. DR4 also plays an important role in juvenile diabetes. While the DQ8.1 haplotype is associated with disease, there is no known association with the DQB1*0305, DQ8.4 or DQ8.5 haplotypes (see infobox) with autoimmune disease; however, this may be the result of lack of study in populations that carry these and the very low frequency.
In Europe, DQ8 is associated with juvenile diabetes and coeliac disease. The highest risk factor for type 1 diabetes is the HLA DQ8/DQ2.5 phenotype. In parts of eastern Scandinavia both DQ2.5 and DQ8 are high increases frequencies of late onset Type I… (Emphasis mine. I love Swedish textiles. This all coming together.)
I frizzled out toward the end of that paragraph, but I see the increased risk for rheumatoid arthritis and can almost feel the cool heft of the Worst Genes in Family trophy in my hands.