Weekend: visit Yale. Halfway point TrialNet Anti-CD3 teplizumab study. One fun weekend activity = attempt suss out placebo or drug. (Obvious signals drug/no placebo: hideous rash, vomiting, fever, exhaustion…)
Friday. Visual inspection: Jack no rash, except from IV tape. Observe behavior: no nausea/fever, but also not very hearty appetite. CONCLUSION: probably placebo, since no obvs. side effects.
BF: Can you tell me anything like…does the lab work make you think he’s getting the placebo or the drug?
INTERJECTING NURSE: The doctor yesterday told her his white blood cell count is down
DR: Did she?
BF: Well, but she said just a tiny bit, and that it didn’t mean he’s getting the drug. She didn’t really tell me anything–I mean, I’m just asking because I am so, so curious
DR: Right. I can tell you it would be very unusual for the white blood cell count to be going down with the placebo. That is not an effect we typically see with the placebo
BF: Oooh! So you think it’s the drug?
DR: I wouldn’t say that. What I can say is it would be an unusual effect that we would not expect to see with a placebo
Certain Bigfoot questions annoy doctor/nurse. So hold next question in: what point is double blind if every medical person can see lab work & lab work clearly demonstrate WBC lower & ergo drug not placebo?
And then, just before depart, see this:
One more week.